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How does CBD work? Its mechanism of action and its involvement with the endocannabinoid system

How does CBD work? Its mechanism of action and its involvement with the endocannabinoid system

The endocannabinoid system (ECS) is a complex cell signaling system identified in the early 1990s. So far, we know that it plays a key role in regulating a variety of functions and processes, such as:

  • Sleep
  • Mood
  • Appetite
  • Memory
  • Reproduction and fertility
  • Chronic pain
  • Inflammation
  • Other

Why are we interested in telling you about the SEC at Pentalium Pharma?

The ECS needs molecules for its activation and corresponding functioning called endocannabinoids or endogenous cannabinoids.

Yes, as you will be spinning from the previous post, these molecules belong to the same group as the cannabinoids found naturally in many plant species (phytocannabinoids). Nature is amazing. It is possible to find the same molecular entity in a plant species and, at the same time, in your own organism.

We already knew that our body is the most complex biological machine developed over time and its operation integrates a multitude of physiological mechanisms no less than interesting, one of them the functioning of the ECS.

You’re probably familiar with sleep disorders, appetite, stress, or mood swings. I will tell you that, far from attributing its cause to a single factor, the SEC has a lot to say about it. It is responsible for keeping certain conditions of our internal environment in balance, in more technical words, it is responsible for the homeostasis of our organism, which is precisely related to the aforementioned disorders. Homeostasis is a broad and physiologically complex concept because it is closely related to many other mechanisms that regulate the proper functioning of our organs and systems. We want to make it easy for you and we illustrate it to you as follows:

Imagine an orchestra. Musicians would be the organs and systems that act in our body and ensure an adequate development of function. In a higher position is the conductor who ensures the coordination of his musicians. The SEC is our conductor. His role may seem less essential but his skill with the baton is relevant to ensure the success of the function.

And what does our SEC need to achieve success?

You need endocannabinoids. When we talk about endocannabinoids we refer to cannabinoids that our own body produces from the intake of certain nutrients. Hence the importance of food.

It is known that animal and plant sources rich inomega 3 and 6 fatty acids provide a high contribution of these endocannabinoids. So you know, the consumption of foods such as salmon, tuna, nuts, sardines, avocado, oils in general (olive, sunflower, coconut, soy, corn, pumpkin seeds, cannabis seeds) and many more, will allow a proper functioning of your SEC.

It is important that you also know that these cannabinoids act on specific receptors(CB1 and CB2),as if it were a key-lock model. These are spread over different parts of our body. So that you can visualize it better, CB1 receptors are mainly found in the central nervous system and CB2 in the peripheral nervous system, especially in immune cells.

Endocannabinoids can bind to any of the receptors and regulate mechanisms of pain, inflammation, or autoimmune disorders, among many others. Some studies suggest that a deficit of these molecules could justify the appearance of migraine and fibromyalgia, among other disorders.

So, if endocannabinoids seem to play a key role in our body’s homeostasis, could we attach the same importance to phytocannabinoids?

As we have mentioned before, both substances have very similar structures with the difference that some are produced endogenously and others are present in nature in many plant species. Everything presages that the operation of both is very similar.

While it is true that the details of how CBD interacts in our body is still to be defined, clinical research indicates that it acts on the same receptors contributing to the aforementioned functions and manifesting a whole range of therapeutic possibilities.

In any case, in our country the consumption of CBD is not allowed from a regulatory point of view although its topical application through the use of cosmetics as we mentioned last week in this post. So far, we encourage you to use CBD topically to relieve pain and inflammatory processes and maintain a diet rich in omega 3 and 6 fatty acids to ensure an adequate level of endocannabinoids in your body.

See you very soon!

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